DrugAge entry for Sesamin

Name: Sesamin
Synonyms: (+)-Segamin • (+)-Sesamin • (+/-)-Sesamin • 1,3-Benzodioxole, 5,5'-(tetrahydro-1H,3H-furo(3,4-c)furan-1,4-diyl)bis-, (1S-(1alpha,3a alpha,4alpha,6a alpha))- • 5-[(3S,3aR,6S,6aR)-3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole • 607-80-7 • 81602-22-4 • AI3-00811 • Asarinin • C20H18O6 • CHEBI:66470 • D-(+)-Sesamin • Episesamin • Fagarol • l-sesamin • MFCD00216134 • NSC 36403 • pseudocubebin • sesamin • Sesamin (Fagarol) • Sesamin dl-form [MI] • Sesamin, (+/-)- • Sezamin • SMR000445559 • UNII-S7946O4P76
CAS Number: 607-80-7
IUPAC Name: 5-[(3S,3aR,6S,6aR)-3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole
PubChem CID: 72307

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Sesamin

Average/Median Lifespan
Max Lifespan
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References

Yaguchi, Y et al. (2014) Influence of oral supplementation with sesamin on longevity of Caenorhabditis elegans and the host defense. Eur J Nutr 53(8)1659-1668 PubMed
Nakatani Y, et al. (2018) Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans. Eur J Nutr () PubMed
Roongpetch Keowkase (2018) Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans Biomedicine & Pharmacotherapy 107()656-664 PubMed

DGIdb Human Drug-Gene Interactions for Sesamin

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Sesamin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id