DrugAge entry for SKF83959 hydrobromide

Name: SKF83959 hydrobromide
Synonyms: 6-CHLORO-2,3,4,5-TETRAHYDRO-3-METHYL-1-(3-METHYLPHENYL)-1H-3-BENZAZEPINE-7,8-DIOL HYDROBROMIDE • 6-chloro-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrobromide • 6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide • 67287-95-0 • 67287-95-0(SKF-83959 HBr) • 80751-85-5 • 9-chloro-3-methyl-5-(3-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol;hydrobromide • AKOS024456929 • CCG-222371 • CHEBI:63996 • CHEMBL520992 • DTXSID9042629 • EU-0101067 • LP01067 • MFCD03792727 • MLS002153381 • NCGC00094346-01 • NCGC00261752-01 • SCHEMBL12610614 • SKF 83959 hydrobromide • SKF-83959 HBr • SKF-83959 hydrobromide • skf83959 hydrobromide • SR-01000076126 • Tox21_501067
CAS Number: 67287-95-0
IUPAC Name: 9-chloro-3-methyl-5-(3-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol;hydrobromide
PubChem CID: 11957685

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for SKF83959 hydrobromide

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for SKF83959 hydrobromide

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for SKF83959 hydrobromide

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id