DrugAge entry for Rotenone

Name
Rotenone 
Synonyms
(-)-cis-Rotenone • (-)-Rotenone • 83-79-4 • Barbasco • Canex • Cube root • Cube-Pulver • Dactinol • Deril • Derrin • Derris • Dri-Kil • Liquid Derris • Nicouline • Noxfire • Noxfish • Paraderil • Ronone • Rotefive • Rotefour • Rotenon • rotenone • Rotessenol • Rotocide • Tubatoxin 
CAS Number
83-79-4 
IUPAC Name
 
PubChem CID
6758 
SEP-L1000 side effects
Abdominal pain, Asthenia, Body temperature increased, Constipation, Decreased appetite, Dermatitis, Diarrhoea, Dizziness, Dyspepsia, Flatulence, Headache, Hyperhidrosis, Hypersensitivity, Infection, Insomnia, Malaise, Nausea, Oedema, Pain, Paraesthesia, Pruritus, Rash, Somnolence, Urticaria, Vomiting 

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Rotenone


References

Schmeisser, S et al. (2013) Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension. Mol Metab 2(2)92-9102 PubMed
Scialo F, et al. (2016) Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metabolism () PubMed
Baumgart M, et al. (2016) Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan. Cell Syst () PubMed
Baumgart M, et al. (2016) Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan. Cell Syst () PubMed

DGIdb Human Drug-Gene Interactions for Rotenone

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Rotenone

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id