DrugAge entry for Rotenone
- Name
- Rotenone
- Synonyms
- (-)-cis-Rotenone • (-)-Rotenone • 83-79-4 • Barbasco • Canex • Cube root • Cube-Pulver • Dactinol • Deril • Derrin • Derris • Dri-Kil • Liquid Derris • Nicouline • Noxfire • Noxfish • Paraderil • Ronone • Rotefive • Rotefour • Rotenon • rotenone • Rotessenol • Rotocide • Tubatoxin
- CAS Number
- 83-79-4
- IUPAC Name
- PubChem CID
- 6758
- SEP-L1000 side effects
- Abdominal pain, Asthenia, Body temperature increased, Constipation, Decreased appetite, Dermatitis, Diarrhoea, Dizziness, Dyspepsia, Flatulence, Headache, Hyperhidrosis, Hypersensitivity, Infection, Insomnia, Malaise, Nausea, Oedema, Pain, Paraesthesia, Pruritus, Rash, Somnolence, Urticaria, Vomiting
Summary
| Species | No. Entries | MAX(Avg/Med Lifespan Change %) | MEAN(Avg/Med Lifespan Change %) | MAX(Max Lifespan Change %) | MEAN(Max Lifespan Change %) |
|---|
Results
| Compound/Formulation | Species | Sex | Strain | Dosage | Avg/Med Lifespan Change (%) | Avg/Med Lifespan Significance | Max Lifespan Change (%) | Reference |
|---|
Lifespan Charts for Rotenone
- Average/Median Lifespan
- Max Lifespan
- Hide Charts
References
Schmeisser, S et al. (2013) Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension. Mol Metab 2(2)92-9102 PubMedScialo F, et al. (2016) Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metabolism () PubMed
Baumgart M, et al. (2016) Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan. Cell Syst () PubMed
Baumgart M, et al. (2016) Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan. Cell Syst () PubMed
Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed
DGIdb Human Drug-Gene Interactions for Rotenone
| Interaction Types | Gene Symbol | Common Name | HGNC Id | DGIdb Sources | References |
|---|---|---|---|---|---|
Stitch DB Human Drug-Protein Interactions for Rotenone
Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.
| Ensembl Id | StringDB Id |
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