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DrugAge entry for Resveratrol

Name
Resveratrol 
Synonyms
(E)-5-(4-Hydroxystyryl)benzene-1,3-diol • (E)-5-(p-Hydroxystyryl)resorcinol • (E)-resveratrol • 3,4',5-Stilbenetriol • 3,4',5-trihydroxy-stilbene • 3,4',5-Trihydroxy-trans-stilbene • 3,4',5-Trihydroxystilbene • 3,5,4'-Trihydroxy-trans-stilbene • 3,5,4'-Trihydroxystilbene • 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol • 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol • 5-[(E)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol • 501-36-0 • CHEBI:45713 • Resveratol • resveratrol • Resveratrol, natural • Resvida • SRT 501 • SRT-501 • SRT501 • trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene • trans-3,4',5-trihydroxystilbene • trans-resveratrol • UNII-Q369O8926L 
CAS Number
501-36-0 
IUPAC Name
5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol 
PubChem CID
445154 
SEP-L1000 side effects
Abdominal pain, Anxiety, Asthenia, Dermatitis, Diarrhoea, Dizziness, Dyspepsia, Dyspnoea, Haemorrhage, Headache, Hepatitis, Hyperhidrosis, Hypersensitivity, Nausea, Oedema, Pain, Paraesthesia, Pruritus, Rash, Urticaria, Vertigo, Vomiting 

Summary

Species No. Entries MAX(Avg/Med Lifespan Change %) MEAN(Avg/Med Lifespan Change %) MAX(Max Lifespan Change %) MEAN(Max Lifespan Change %)

Results

Compound/Formulation Species Sex Strain Dosage Avg/Med Lifespan Change (%) Avg/Med Lifespan Significance Max Lifespan Change (%) Reference

Lifespan Charts for Resveratrol


References

Howitz, KT et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425(6954)191-196 PubMed
Wood, JG et al. (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430(7000)686-689 PubMed
Kaeberlein, M et al. (2005) Substrate-specific activation of sirtuins by resveratrol. J. Biol. Chem. 280(17)17038-17045 PubMed
Viswanathan, M et al. (2005) A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev. Cell 9(5)605-615 PubMed
Valenzano, DR et al. (2006) Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr. Biol. 16(3)296-300 PubMed
Yang, H et al. (2007) Design and synthesis of compounds that extend yeast replicative lifespan. Aging Cell 6(1)35-43 PubMed
Gruber, J et al. (2007) Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans. Ann. N. Y. Acad. Sci. 1100()530-542 PubMed
Bass, TM et al. (2007) Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech. Ageing Dev. 128(10)546-552 PubMed
Zou, S et al. (2009) The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly. Exp. Gerontol. 44(6-7)472-476 PubMed
Morselli, E et al. (2010) Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 1()e10 PubMed
Wang, C et al. (2013) The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster. Age (Dordr) 35(1)69-81 PubMed
Sun, K et al. (2012) Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression. Biosci. Biotechnol. Biochem. 76(4)640-645 PubMed
Rascón, B et al. (2012) The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction. Aging (Albany NY) 4(7)499-508 PubMed
Yu, X and Li, G (2012) Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri. Exp. Gerontol. 47(12)940-949 PubMed
Genade, T and Lang, DM (2013) Resveratrol extends lifespan and preserves glia but not neurons of the Nothobranchius guentheri optic tectum. Exp. Gerontol. 48(2)202-212 PubMed
Sun, K et al. (2013) A Steroidal Saponin from Ophiopogon japonicus Extends the Lifespan of Yeast via the Pathway Involved in SOD and UTH1. Int J Mol Sci 14(3)4461-4475 PubMed
Houtkooper, RH et al. (2013) Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 497(7450)451-457 PubMed
Kim, E et al. (2014) Resveratrol and food effects on lifespan and reproduction in the model crustacean Daphnia. J Exp Zool A Ecol Genet Physiol 321(1)48-56 PubMed
Liu, T et al. (2015) Resveratrol Attenuates Oxidative Stress and Extends Life Span in the Annual Fish Nothobranchius guentheri. Rejuvenation Res 18(3)225-233 PubMed
Kim, J et al. (2015) The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1. Mol. Cell. Endocrinol. 412()216-225 PubMed
Statts, S et al. () Dietary Resveratrol Does Not Affect Life Span, Body Composition, Stress Response, and Longevity-Related Gene Expression in Drosophila melanogaster Int J Mol Sci () PubMed
Fischer N, et al. (2017) The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. J Pharm Pharmacol () PubMed
Lee J, et al (2016) Brief Communication: SIR-2.1-dependent lifespan extension of Caenorhabditis elegans by oxyresveratrol and resveratrol Exp Biol Med (Maywood) () PubMed
Desjardins D, et al. (2017) Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. Aging Cell () PubMed
Pannakal ST, et al. (2017) Longevity effect of a polysaccharide from Chlorophytum borivilianum on Caenorhabditis elegans and Saccharomyces cerevisiae () PubMed
Orlandi, I et al. (2017) During yeast chronological aging resveratrol supplementation results in a short-lived phenotype Sir2-dependent. Redox biology 12()745-754 PubMed
Lim YP, et al. (2018) Synthetic Enzymology and the Fountain of Youth: Repurposing Biology for Longevity ASC Omega () PubMed
Mi XN, et al. (2018) Methyl 3,4-Dihydroxybenzoate Enhances Resistance to Oxidative Stressors and Lifespan in C. elegans Partially via daf-2/daf-16 International journal of molecular sciences () PubMed
Lan Xiang (2011) Anti-aging effects of phloridzin, an apple polyphenol, on yeast via the SOD and Sir2 genes Bioscience, Biotechnology & Biochemistry 75(5)854-858 PubMed
Wei Chen (2013) Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans Journal of Pharmacy and Pharmacology 65(5)682-688 PubMed
Longze Zhang (2012) Quinic acid could be a potential rejuvenating natural compound by improving survival of Caenorhabditis elegans under deleterious conditions Rejuvenation Research 15(6)573-83 PubMed
Rodrigo Dutra Nunes (2016) Polyphenol-Rich Diets Exacerbate AMPK-Mediated Autophagy, Decreasing Proliferation of Mosquito Midgut Microbiota, and Extending Vector Lifespan Plos Neglected Tropical Diseases 10(10)e0005034 PubMed
Adiv A Johnson (2015) Resveratrol Fails to Extend Life Span in the Mosquito Anopheles stephensi Rejuvenation Research 18(5)473-8 PubMed
Yanfei Lin (2019) Cucurbitacin B Exerts Antiaging Effects in Yeast by Regulating Autophagy and Oxidative Stress Oxidative Medicine and Cellular Longevity 2019() PubMed
Banse, SA et al. (2019) Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions. Geroscience 41(6)945-960 PubMed
Miller, RA et al. (2011) Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. The journals of gerontology. Series A, Biological sciences and medical sciences 66(2)191-201 PubMed
Strong, R et al. (2013) Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 68(1)6-16 PubMed

DGIdb Human Drug-Gene Interactions for Resveratrol

Interaction Types Gene Symbol Common Name HGNC Id DGIdb Sources References

Stitch DB Human Drug-Protein Interactions for Resveratrol

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id