DrugAge entry for Rapamycin
- Name
- Rapamycin
- Synonyms
- (-)-Rapamycin • 53123-88-9 • Antibiotic AY 22989 • AY 22989 • AY-22989 • C51H79NO13 • CCRIS 9024 • CHEBI:9168 • DE-109 • DSSTox_CID_3582 • DSSTox_GSID_23582 • DSSTox_RID_77091 • HSDB 7284 • MFCD00867594 • NCGC00021305-05 • NSC 226080 • RAPA • Rapammune • Rapamune • Rapamycin • Rapamycin (Sirolimus) • Sirolimus • sirolimusum • Supralimus • UNII-W36ZG6FT64 • W36ZG6FT64 • WY-090217
- CAS Number
- 53123-88-9
- IUPAC Name
- PubChem CID
- 5284616
- SEP-L1000 side effects
- Abdominal distension, Abdominal pain, Abscess, Acidosis, Acne, Agitation, Alanine aminotransferase increased, Albuminuria, Anaemia, Anaphylactoid reaction, Angioedema, Angiopathy, Anorectal disorder, Anxiety, Arthralgia, Arthropathy, Ascites, Aspartate aminotransferase increased, Asthenia, Asthma, Atelectasis, Atrial fibrillation, Azoospermia, Azotaemia, Back pain, Bacterial infection, Basal cell carcinoma, Benign neoplasm of skin, Bladder pain, Blood alkaline phosphatase increased, Blood cholesterol increased, Blood creatinine increased, Blood lactate dehydrogenase increased, Blood urea increased, Body temperature increased, Bone pain, Bronchiolitis, Bronchitis, Candida infection, Carcinogenicity, Cardiac failure, Cardiac failure congestive, Cardiac fibrillation, Cardiomegaly, Cataract, Cellulitis, Chest pain, Chills, Confusional state, Conjunctivitis, Constipation, Cough, Cytomegalovirus infection, Deafness, Death, Decreased appetite, Deep vein thrombosis, Dehydration, Dermatitis, Dermatitis exfoliative, Di
Summary
| Species | No. Entries | MAX(Avg/Med Lifespan Change %) | MEAN(Avg/Med Lifespan Change %) | MAX(Max Lifespan Change %) | MEAN(Max Lifespan Change %) |
|---|
Results
| Compound/Formulation | Species | Gender | Strain | Dosage | Avg/Med Lifespan Change (%) | Avg/Med Lifespan Significance | Max Lifespan Change (%) | Reference |
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Lifespan Charts for Rapamycin
- Average/Median Lifespan
- Max Lifespan
- Hide Charts
References
Bjedov, I et al. (2010) Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab. 11(1)35-46 PubMedRobida-Stubbs, S et al. (2012) TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15(5)713-724 PubMed
Houtkooper, RH et al. (2013) Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 497(7450)451-457 PubMed
Calvert, S et al. (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15(2)256-266 PubMed
Wu Q, et al. (2017) 2,5-Dimethyl-Celecoxib Extends Drosophila Life Span via a Mechanism That Requires Insulin and Target of Rapamycin Signaling. J Gerontol A Biol Sci Med Sci () PubMed
Chen Di, et al. (2013) Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans Cell Reports () PubMed
Mi XN, et al. (2018) Methyl 3,4-Dihydroxybenzoate Enhances Resistance to Oxidative Stressors and Lifespan in C. elegans Partially via daf-2/daf-16 International journal of molecular sciences () PubMed
Janssens, GE et al. (2019) Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell Rep 27(2)467-480.e6 PubMed
Admasu, TD et al. (2018) Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling. Dev Cell 47(1)67-79.e5 PubMed
Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed
Harrison, DE et al. (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460(7253)392-395 PubMed
Miller, RA et al. (2011) Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. The journals of gerontology. Series A, Biological sciences and medical sciences 66(2)191-201 PubMed
Anisimov, VN et al. (2011) Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. Cell Cycle 10(24)4230-4236 PubMed
Miller, RA et al. (2014) Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell 13(3)468-477 PubMed
Fok, WC et al. (2014) Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS ONE 9(1)e83988 PubMed
Arriola Apelo SI, et al. (2016) Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice J Gerontol A Biol Sci Med Sci () PubMed
Bitto A, et al. (2016) Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice eLIFE () PubMed
Strong, R et al. (2020) Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects. Aging cell 19(11)e13269 PubMed
DGIdb Human Drug-Gene Interactions for Rapamycin
| Interaction Types | Gene Symbol | Common Name | HGNC Id | DGIdb Sources | References |
|---|---|---|---|---|---|
Stitch DB Human Drug-Protein Interactions for Rapamycin
Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.
| Ensembl Id | StringDB Id |
|---|