DrugAge entry for Quercetin

Name: Quercetin
Synonyms: 117-39-5 • 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one • 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one • 3,3',4',5,7-Pentahydroxyflavone • 3,5,7,3',4'-Pentahydroxyflavone • C.I. 75670 • C.I. Natural red 1 • C.I. Natural Yellow 10 • CI Natural Yellow 10 • Cyanidelonon 1522 • Flavin meletin • Kvercetin • Kvercetin [Czech] • Meletin • Natural Yellow 10 • quercetin • Quercetin content • Quercetine • Quercetol • Quercitin • Quertin • Quertine • Sophoretin • T-Gelb bzw. grun 1 • Xanthaurine
CAS Number: 117-39-5
IUPAC Name: 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one
PubChem CID: 5280343
SEP-L1000 side effects: Abdominal pain, Body temperature increased, Confusional state, Decreased appetite, Diarrhoea, Dizziness, Dyspepsia, Erythema, Haemorrhage, Headache, Hepatitis, Hyperhidrosis, Hypersensitivity, Malaise, Myalgia, Nausea, Oedema, Pain, Pruritus, Rash, Somnolence, Tachycardia, Thrombocytopenia, Urticaria, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Quercetin

Average/Median Lifespan
Max Lifespan
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References

Kampkötter, A et al. (2008) Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 149(2)314-323 PubMed
Saul, N et al. (2008) Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved? Mech. Ageing Dev. 129(10)611-613 PubMed
Pietsch, K et al. (2009) Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43. Biogerontology 10(5)565-578 PubMed
Xue, YL et al. (2011) Isolation and Caenorhabditis elegans lifespan assay of flavonoids from onion. J. Agric. Food Chem. 59(11)5927-5934 PubMed
Pietsch, K et al. (2012) Meta-Analysis of Global Transcriptomics Suggests that Conserved Genetic Pathways are Responsible for Quercetin and Tannic Acid Mediated Longevity in C. elegans. Front Genet 3()48 PubMed
Proshkina E, et al. (2016) Geroprotective and Radioprotective Activity of Quercetin, (-)-Epicatechin, and Ibuprofen in Drosophila melanogaster Front Pharmacol () PubMed
Gregor Grünz (2012) Structural features and bioavailability of four flavonoids and their implications for lifespan-extending and antioxidant actions in C. elegans Mechanisms of Ageing and Development 133(1)1-10 PubMed
Felipe Surco-Laos (2011) Effects of O-methylated metabolites of quercetin on oxidative stress, thermotolerance, lifespan and bioavailability on Caenorhabditis elegans Food & Function 2(8)445-56 PubMed
Rodrigo Dutra Nunes (2016) Polyphenol-Rich Diets Exacerbate AMPK-Mediated Autophagy, Decreasing Proliferation of Mosquito Midgut Microbiota, and Extending Vector Lifespan Plos Neglected Tropical Diseases 10(10)e0005034 PubMed
Teresia M. Njoroge (2021) Specific phytochemicals in floral nectar up-regulate genes involved in longevity regulation and xenobiotic metabolism, extending mosquito life span Ecology and Evolution 11(12)8363-8380 PubMed
Warnsmann, V et al. (2018) Quercetin-Induced Lifespan Extension in Front Genet 9()160 PubMed
Jones E and Hughes RE (1982) Quercetin, flavonoids and the life-span of mice. Exp Gerontol () PubMed

DGIdb Human Drug-Gene Interactions for Quercetin

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Quercetin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id