DrugAge entry for Quercetin

Name
Quercetin 
Synonyms
117-39-5 • 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one • 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one • 3,3',4',5,7-Pentahydroxyflavone • 3,5,7,3',4'-Pentahydroxyflavone • C.I. 75670 • C.I. Natural red 1 • C.I. Natural Yellow 10 • CI Natural Yellow 10 • Cyanidelonon 1522 • Flavin meletin • Kvercetin • Kvercetin [Czech] • Meletin • Natural Yellow 10 • quercetin • Quercetin content • Quercetine • Quercetol • Quercitin • Quertin • Quertine • Sophoretin • T-Gelb bzw. grun 1 • Xanthaurine 
CAS Number
117-39-5 
IUPAC Name
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one 
PubChem CID
5280343 
SEP-L1000 side effects
Abdominal pain, Body temperature increased, Confusional state, Decreased appetite, Diarrhoea, Dizziness, Dyspepsia, Erythema, Haemorrhage, Headache, Hepatitis, Hyperhidrosis, Hypersensitivity, Malaise, Myalgia, Nausea, Oedema, Pain, Pruritus, Rash, Somnolence, Tachycardia, Thrombocytopenia, Urticaria, Vomiting 

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Quercetin


References

Kampkötter, A et al. (2008) Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 149(2)314-323 PubMed
Saul, N et al. (2008) Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved? Mech. Ageing Dev. 129(10)611-613 PubMed
Pietsch, K et al. (2009) Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43. Biogerontology 10(5)565-578 PubMed
Xue, YL et al. (2011) Isolation and Caenorhabditis elegans lifespan assay of flavonoids from onion. J. Agric. Food Chem. 59(11)5927-5934 PubMed
Pietsch, K et al. (2012) Meta-Analysis of Global Transcriptomics Suggests that Conserved Genetic Pathways are Responsible for Quercetin and Tannic Acid Mediated Longevity in C. elegans. Front Genet 3()48 PubMed
Jones E and Hughes RE (1982) Quercetin, flavonoids and the life-span of mice. Exp Gerontol () PubMed
Proshkina E, et al. (2016) Geroprotective and Radioprotective Activity of Quercetin, (-)-Epicatechin, and Ibuprofen in Drosophila melanogaster Front Pharmacol () PubMed

DGIdb Human Drug-Gene Interactions for Quercetin

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Quercetin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id