DrugAge entry for Propafenone hydrochloride

Name: Propafenone hydrochloride
Synonyms: 1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one hydrochloride • 1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-, hydrochloride • 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone hydrochloride • 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one hydrochloride • 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride • 1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one hydrochloride • 34183-22-7 • Arythmol • Baxarytmon • C21H28ClNO3 • CHEBI:8466 • Fenoprain • MFCD00079243 • MLS000069682 • Propafenon hydrochlorid • Propafenone (hydrochloride) • Propafenone D7 Hydrochloride • Propafenone HCl • PROPAFENONE HYDROCHLORIDE • Rhythmonorm • Rythmol • Rythmol SR • Rytmonorm • SA-79 (hydrochloride) • SMR000058493
CAS Number: 34183-22-7
IUPAC Name: 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride
PubChem CID: 36708

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Propafenone hydrochloride

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Derisbourg, MJ et al. (2021) Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation. Nat Commun 12(1)1678 PubMed

DGIdb Human Drug-Gene Interactions for Propafenone hydrochloride

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Propafenone hydrochloride

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id