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DrugAge entry for Promethazine hydrochloride

Name
Promethazine hydrochloride 
Synonyms
58-33-3 • Allerfen • Diprasine • Diprazin • Duplamin • Farganesse • Fellozine • Fenergan • Frinova • Ganphen • Goodnight • Hibechin • Histantil • Kinetosin • N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride • Phenadoz • Phenergan • Pipolfen • Pipolphen • Plletia • Promethazine chloride • Promethazine Hcl • PROMETHAZINE HYDROCHLORIDE • Promethiazin • Romergan 
CAS Number
58-33-3 
IUPAC Name
N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride 
PubChem CID
6014 
SEP-L1000 side effects
Abscess, Acidosis, Agitation, Agranulocytosis, Apnoea, Asthma, Ataxia, Bradycardia, Catatonia, Confusional state, Convulsion, Coordination abnormal, Death, Delirium, Dermatitis, Diplopia, Disorientation, Dizziness, Dry mouth, Dyskinesia, Elderly, Erythema, Euphoric mood, Extrapyramidal disorder, Extravasation, Fatigue, Flushing, Gangrene, Gastrointestinal disorder, Hallucination, Hyperreflexia, Hypertonia, Hypotension, Injection site reaction, Insomnia, Jaundice, Leukopenia, Loss of consciousness, Muscle spasms, Mydriasis, Nasal congestion, Necrosis, Nervousness, Neuroleptic malignant syndrome, Nightmare, Oculogyric crisis, Oedema, Paralysis, Phlebitis, Photosensitivity reaction, Protrusion tongue, Purpura, Rash, Respiratory depression, Somnolence, Sudden death, Swelling, Syncope, Tachycardia, Tension, Thrombocytopenia, Thrombocytopenic purpura, Thrombophlebitis, Thrombosis, Tinnitus, Torticollis, Tremor, Venous thrombosis, Vision blurred 

Summary

Species No. Entries MAX(Avg/Med Lifespan Change %) MEAN(Avg/Med Lifespan Change %) MAX(Max Lifespan Change %) MEAN(Max Lifespan Change %)

Results

Compound/Formulation Species Sex Strain Dosage Avg/Med Lifespan Change (%) Avg/Med Lifespan Significance Max Lifespan Change (%) Reference

Lifespan Charts for Promethazine hydrochloride


References

Ye, X et al. (2014) A pharmacological network for lifespan extension in Caenorhabditis elegans. Aging Cell 13(2)206-215 PubMed
Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed
Hochschild, R. (1971) Effect of membrane stabilizing drugs on mortality in Drosophila melanogaster. Exp Gerontol 6(2)133-151 PubMed

DGIdb Human Drug-Gene Interactions for Promethazine hydrochloride

Interaction Types Gene Symbol Common Name HGNC Id DGIdb Sources References

Stitch DB Human Drug-Protein Interactions for Promethazine hydrochloride

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id