DrugAge entry for Promazine Hydrochloride

Name: Promazine Hydrochloride
Synonyms: 10-(3-(Dimethylamino)propyl)phenothiazine hydrochloride • 10-(3-(Dimethylamino)propyl)phenothiazine monohydrochloride • 10-(gamma-Dimethylamino-n-propyl)phenothiazine hydrochloride • 10H-Phenothiazine-10-propanamine, N,N-dimethyl-, monohydrochloride • 53-60-1 • DSSTox_CID_26949 • DSSTox_GSID_46949 • DSSTox_RID_82026 • MLS000069671 • N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride • N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride • N-(3-(Dimethylamino)propyl)phenothiazine hydrochloride • Promazine (hydrochloride) • Promazine Hcl • PROMAZINE HYDROCHLORIDE • Promazine hydrochloride (USP) • Promazine hydrochloride [USP] • Promazine monohydrochloride • RP 4560 • SMR000058499 • Sparine • Starazin • Talofen • U16EOR79U4 • UNII-U16EOR79U4
CAS Number: 53-60-1
IUPAC Name: N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride
PubChem CID: 5887

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Promazine Hydrochloride

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Promazine Hydrochloride

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Promazine Hydrochloride

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id