DrugAge entry for Pirenperone

Name: Pirenperone
Synonyms: 3-(2-(4-(4-Fluorobenzoyl)piperidin-1-yl)ethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one • 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-2-methylpyrido[1,2-a]pyrimidin-4-one • 75444-65-4 • CAS-75444-65-4 • CHEMBL18331 • DSSTox_CID_25182 • DSSTox_GSID_45182 • DSSTox_RID_80730 • EINECS 278-213-5 • MLS000069365 • NCGC00015784-07 • Pirenperona • Pirenperona [INN-Spanish] • Pirenperone • Pirenperone [USAN:INN:BAN] • Pirenperonum • Pirenperonum [INN-Latin] • Prestwick_858 • R 47465 • R-47,465 • SMR000058507 • Spectrum_001584 • SR-01000002998 • UNII-Y9FMC4513X • Y9FMC4513X
CAS Number: 75444-65-4
IUPAC Name: 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-2-methylpyrido[1,2-a]pyrimidin-4-one
PubChem CID: 4847

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Pirenperone

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Pirenperone

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Pirenperone

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id