DrugAge entry for Phenoxybenzamine Hydrochloride

Name: Phenoxybenzamine Hydrochloride
Synonyms: 2-(N-Benzyl-2-chloroethylamino)-1-phenoxypropane hydrochloride • 63-92-3 • 63-92-3 (HCl) • Bensylyt NEN • CHEBI:8078 • Dibenzyline • Dibenzyline hydrochloride • Dibenzyran • DSSTox_CID_1127 • DSSTox_GSID_21127 • DSSTox_RID_75958 • MFCD00055152 • MLS000069374 • N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine hydrochloride • N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride • N-2-Phenoxyisopropyl-N-benzyl-chloroethylamine hydrochloride • N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine hydrochloride • N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine;hydrochloride • NCI-C01661 • Phenoxybenzamine (hydrochloride) • Phenoxybenzamine chloride • Phenoxybenzamine Hcl • Phenoxybenzamine hydrochloride • Phenoxybenzamine.HCl • SMR000058422
CAS Number: 63-92-3
IUPAC Name: N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine;hydrochloride
PubChem CID: 5284441

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Phenoxybenzamine Hydrochloride

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Phenoxybenzamine Hydrochloride

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Phenoxybenzamine Hydrochloride

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id