DrugAge entry for Phenformin

Name: Phenformin
Synonyms: 114-86-3 • beta-PEBG • Cronoformin • Db-retard • Debeone • Diabis • Dibiraf • Dibotin • Fenfoduron • Fenformin • Fenformina • Fenormin • Glukopostin • Glyphen • Lentobetic • N-Phenethylbiguanide • Normoglucina • Pedg • Phenethyldiguanide • PHENFORMIN • Phenformine • Phenforminum • Phenformix • Phenylethylbiguanide • Retardo
CAS Number: 114-86-3
IUPAC Name: 1-(diaminomethylidene)-2-(2-phenylethyl)guanidine
PubChem CID: 8249
SEP-L1000 side effects: Abdominal pain, Anxiety, Asthenia, Body temperature increased, Confusional state, Constipation, Convulsion, Decreased appetite, Diarrhoea, Dizziness, Dyspepsia, Headache, Hepatitis, Hyperhidrosis, Hypersensitivity, Hypotension, Insomnia, Nausea, Oedema, Pain, Paraesthesia, Pruritus, Rash, Somnolence, Tachycardia, Thrombocytopenia, Tremor, Urticaria, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Phenformin

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Cabreiro, F et al. (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153(1)228-239 PubMed
Anisimov, VN et al. (2003) Insulin and longevity: antidiabetic biguanides as geroprotectors. Biogerontology 4(5)297-307 PubMed

DGIdb Human Drug-Gene Interactions for Phenformin

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Phenformin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id