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DrugAge entry for Pergolide methanesulfonate

Name
Pergolide methanesulfonate 
Synonyms
66104-23-2 • 8-beta-((Methylthio)methyl)-6-propylergoline methanesulfonate • 8-beta-((Methylthio)methyl)-6-propylergoline monomethane sulfonate • 8beta-((Methylthio)methyl)-6-propylergoline monomethanesulfonate • CHEBI:8021 • CHEMBL1275 • CPD000058504 • DSSTox_CID_20583 • DSSTox_GSID_40583 • DSSTox_RID_77029 • Ergoline, 8-((methylthio)methyl)-6-propyl-, monomethanesulfonate, (8beta)- • Ergoline, 8-beta-((methylthio)methyl)-6-propyl-, methanesulfonate (1:1) • LY 127809 • LY127809 • MLS000069837 • NCGC00017366-04 • Pergolide (mesylate) • Pergolide mesilate • PERGOLIDE MESYLATE • PERGOLIDE MESYLATE SALT • Pergolide mesylate [USAN] • Pergolide Methanesulfonate • Pergolide methanesulfonate salt • SMR000058504 • UNII-55B9HQY616 
CAS Number
66104-23-2 
IUPAC Name
(6aR,9R,10aR)-9-(methylsulfanylmethyl)-7-propyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline;methanesulfonic acid 
PubChem CID
47812 
SEP-L1000 side effects
Abdominal distension, Abdominal pain, Abnormal dreams, Abscess, Acidosis, Acne, Adenoma benign, Agitation, Akathisia, Akinesia, Alopecia, Amenorrhoea, Amnesia, Anaemia, Anaemia megaloblastic, Angina pectoris, Angiopathy, Anxiety, Apathy, Aphthous stomatitis, Apnoea, Arrhythmia, Arthralgia, Arthritis, Asthenia, Asthma, Ataxia, Atrial fibrillation, Atrioventricular block, Atrophy, Back pain, Benign neoplasm of skin, Blindness, Body temperature decreased, Body temperature increased, Bone pain, Bradycardia, Brain oedema, Breast cancer, Breast engorgement, Breast feeding, Breast pain, Bronchitis, Bursitis, Cachexia, Candida infection, Cardiac arrest, Cardiac failure, Cardiac failure congestive, Cardiac fibrillation, Cataract, Cellulitis, Cerebral haemorrhage, Cerebral ischaemia, Cerebrovascular accident, Chest pain, Chills, Cholecystitis, Cholelithiasis, Choreoathetosis, Colitis, Coma, Confusional state, Conjunctivitis, Constipation, Convulsion, Coordination abnormal, Cough, Cyanosis, Cystitis, Deafness, Decreased 

Summary

Species No. Entries MAX(Avg/Med Lifespan Change %) MEAN(Avg/Med Lifespan Change %) MAX(Max Lifespan Change %) MEAN(Max Lifespan Change %)

Results

Compound/Formulation Species Sex Strain Dosage Avg/Med Lifespan Change (%) Avg/Med Lifespan Significance Max Lifespan Change (%) Reference

Lifespan Charts for Pergolide methanesulfonate


References

Ye, X et al. (2014) A pharmacological network for lifespan extension in Caenorhabditis elegans. Aging Cell 13(2)206-215 PubMed
Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Pergolide methanesulfonate

Interaction Types Gene Symbol Common Name HGNC Id DGIdb Sources References

Stitch DB Human Drug-Protein Interactions for Pergolide methanesulfonate

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id