DrugAge entry for Palmatine

Name: Palmatine
Synonyms: 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium • 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium • 2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium • 3486-67-7 • 5,6-Dihydro-2,3,9,10-tetramethoxy-dibenzo[a,g]quinolizinium • 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo(a,g)quinolizinium • 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium • 7,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxyberbinium • Berbericinine • BRN 1555498 • Burasaine • C21H22NO4 • Calystigine • CHEBI:16096 • CHEMBL274189 • Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy- • Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy- • G50C034217 • GNF-PF-4086 • Hindarinine • O,O-Dimethyldemethyleneberberine • Palmatin • Palmatine • SR-01000841226 • UNII-G50C034217
CAS Number: 3486-67-7
IUPAC Name: 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium
PubChem CID: 19009

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Palmatine

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Palmatine

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Palmatine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id