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DrugAge entry for Orotate

Name
Orotate 
Synonyms
2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate • 21317-EP2281559A1 • 21317-EP2284172A1 • 21317-EP2314295A1 • 73-97-2 • AG-G-93379 • CHEBI:30839 • DTXSID80363448 • Orotic acidanion • Q27104157 
CAS Number
73-97-2 
IUPAC Name
2,4-dioxo-1H-pyrimidine-6-carboxylate 
PubChem CID
1492348 

Summary

Species No. Entries MAX(Avg/Med Lifespan Change %) MEAN(Avg/Med Lifespan Change %) MAX(Max Lifespan Change %) MEAN(Max Lifespan Change %)

Results

Compound/Formulation Species Sex Strain Dosage Avg/Med Lifespan Change (%) Avg/Med Lifespan Significance Max Lifespan Change (%) Reference

Lifespan Charts for Orotate


References

Wan, QL et al. (2019) Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of Aging (Albany NY) 11(12)3993-4010 PubMed

DGIdb Human Drug-Gene Interactions for Orotate

Interaction Types Gene Symbol Common Name HGNC Id DGIdb Sources References

Stitch DB Human Drug-Protein Interactions for Orotate

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id