DrugAge entry for Nordihydroguaiaretic acid
- Name
- Nordihydroguaiaretic acid
- Synonyms
- 1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis- • 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane • 2,3-Bis(3,4-dihydroxyphenylmethyl)butane • 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol) • 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol • 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol • 500-38-9 • Actinex • beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane • Butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl- • CCRIS 1399 • CHEMBL52 • Dihydronorguaiaretic acid • Dinorguaiaretic acid, dihydro- • EINECS 207-903-0 • MFCD00002206 • NDGA • NORDIHYDROGUAIARETIC ACID • Nordihydroguaiaretic acid (unspecified) • Nordihydroguairaretic acid • nordihydroguaretic acid • Norguaiaretic acid, dihydro- • Norhydroguaiaretic acid • NSC 4291 • NSC 682984 • Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-
- CAS Number
- 500-38-9
- IUPAC Name
- 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
- PubChem CID
- 4534
Summary
| Species | No. Entries | MAX(Avg/Med Lifespan Change %) | MEAN(Avg/Med Lifespan Change %) | MAX(Max Lifespan Change %) | MEAN(Max Lifespan Change %) |
|---|
Results
| Compound/Formulation | Species | Sex | Strain | Dosage | Avg/Med Lifespan Change (%) | Avg/Med Lifespan Significance | Max Lifespan Change (%) | Reference |
|---|
Lifespan Charts for Nordihydroguaiaretic acid
- Average/Median Lifespan
- Max Lifespan
- Hide Charts
References
Richie, JP et al. (1986) Dietary nordihydroguaiaretic acid increases the life span of the mosquito. Proc. Soc. Exp. Biol. Med. 183(1)81-85 PubMedSpindler, SR et al. (2015) Nordihydroguaiaretic Acid Extends the Lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice. J. Gerontol. A Biol. Sci. Med. Sci. 70(12)1479-1489 PubMed
Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed
Tezil, T et al. (2019) Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy. NPJ Aging Mech Dis 5()7 PubMed
Miquel, J et al. (1982) Antioxidants, metabolic rate and aging in Drosophila. Arch Gerontol Geriatr 1(2)159-165 PubMed
Strong, R et al. (2008) Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell 7(5)641-650 PubMed
Flurkey, K et al. (2010) Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 65(12)1275-1284 PubMed
Strong R, et al. (2016) Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer Aging Cell () PubMed
DGIdb Human Drug-Gene Interactions for Nordihydroguaiaretic acid
| Interaction Types | Gene Symbol | Common Name | HGNC Id | DGIdb Sources | References |
|---|---|---|---|---|---|
Stitch DB Human Drug-Protein Interactions for Nordihydroguaiaretic acid
Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.
| Ensembl Id | StringDB Id |
|---|