DrugAge entry for Norcantharidin

Name: Norcantharidin
Synonyms: (+/-)-NCTD • (+/-)-Norcantharidin • 29745-04-8 • 3,6-Endoxohexahydrophthalic anhydride • 4,10-dioxatricyclo[5.2.1.02,6]decane-3,5-dione • 4,10-dioxatricyclo[5.2.1.0<2,6>]decane-3,5-dione • 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro- • 5442-12-6 • 7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic anhydride • 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride • DEMETHYL-CANTHARIDIN • Endothall anhydride • exo-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride • Hexahydro-4,7-epoxyisobenzofuran-1,3-dione • Isocantharidin • MFCD00213361 • NCTD • Norcantharadine • NSC-14003 • NSC-59023
CAS Number: 5442-12-6
IUPAC Name: 4,10-dioxatricyclo[5.2.1.02,6]decane-3,5-dione
PubChem CID: 93004

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Norcantharidin

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Norcantharidin

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Norcantharidin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id