DrugAge entry for Nicotinamide

Name: Nicotinamide
Synonyms: 3-Pyridinecarboxamide • 98-92-0 • Aminicotin • Amixicotyn • Austrovit PP • Benicot • Delonin amide • Dipegyl • Endobion • Hansamid • Inovitan PP • niacinamide • Nicobion • nicotinamide • Nicotinic acid amide • Nicotinic amide • Nicotylamide • Nikotinamid • Papulex • Pelmine • Pelonin amide • pyridine-3-carboxamide • Savacotyl • Vi-Nicotyl • vitamin PP
CAS Number: 98-92-0
IUPAC Name: pyridine-3-carboxamide
PubChem CID: 936
SEP-L1000 side effects: Abdominal pain, Convulsion, Decreased appetite, Diarrhoea, Dizziness, Dyspnoea, Erythema, Headache, Hypersensitivity, Insomnia, Malaise, Nausea, Oedema, Pain, Paraesthesia, Pruritus, Rash, Somnolence, Tachycardia, Urticaria, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Nicotinamide

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Schmeisser, K et al. (2013) Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat. Chem. Biol. 9(11)693-700 PubMed
Orlandi I, et al. (2017) Nicotinamide supplementation phenocopies SIR2 inactivation by modulating carbon metabolism and respiration during yeast chronological aging. Mech Ageing Dev () PubMed
Mitchell SJ, et al. (2018) Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. () PubMed

DGIdb Human Drug-Gene Interactions for Nicotinamide

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Nicotinamide

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id