DrugAge entry for Naringin

Name: Naringin
Synonyms: (2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one • (2S)-Naringin • (S)-7-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one • (S)-7-((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)tetrahydro-2H-pyran-2-yloxy)-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one • 10236-47-2 • 4'5-diOH-Flavone-7-rhgluc • 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one • aurantiin • C27H32O14 • CHEBI:28819 • CHEMBL451532 • EINECS 233-566-4 • MFCD00148888 • N7TD9J649B • Naringenin 7-O-neohesperidoside • Naringenin 7-O-[alpha-L-rhamn
CAS Number: 10236-47-2
IUPAC Name: 7-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
PubChem CID: 442428
SEP-L1000 side effects: Abdominal pain, Anaemia, Asthenia, Body temperature increased, Chest pain, Confusional state, Constipation, Cough, Decreased appetite, Diarrhoea, Dizziness, Dyspepsia, Dyspnoea, Headache, Hypersensitivity, Hypotension, Insomnia, Malaise, Nausea, Oedema, Pain, Paraesthesia, Pruritus, Rash, Rhinitis, Tachycardia, Urticaria, Vertigo, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Naringin

Average/Median Lifespan
Max Lifespan
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References

Lashmanova E, et al. (2017) The Evaluation of Geroprotective Effects of Selected Flavonoids in Drosophila melanogaster and Caenorhabditis elegans Front. Pharmacol () PubMed
Zhu, Q et al. (2020) A Dihydroflavonoid Naringin Extends the Lifespan of Oxid Med Cell Longev 2020()6069354 PubMed

DGIdb Human Drug-Gene Interactions for Naringin

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Naringin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id