DrugAge entry for Nafadotride

Name: Nafadotride
Synonyms: (+-)-nafadotride • 149649-22-9 • 2-Naphthalenecarboxamide, N-[(1-butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy- • AKOS024257976 • BCP27779 • BDBM50133923 • CCG-101119 • CHEBI:64191 • CHEMBL286252 • DTXSID1042603 • GTPL44 • HMS2052A15 • HMS2232B11 • HMS3267P15 • HMS3370D02 • HMS3394A15 • HMS3414K11 • HMS3678K11 • MLS000758952 • MLS001424218 • N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE • N-[(1-butylpyrrolidin-2-yl)methyl]-4-cyano-1-methoxynaphthalene-2-carboxamide • Nafadotride • NC00369 • SCHEMBL635866 • SMR000466292
CAS Number: 149649-22-9
IUPAC Name: N-[(1-butylpyrrolidin-2-yl)methyl]-4-cyano-1-methoxynaphthalene-2-carboxamide
PubChem CID: 3408722

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Nafadotride

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Nafadotride

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Nafadotride

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id