DrugAge entry for NSC 11926 (Aristolochic acid I)

Name: NSC 11926 (Aristolochic acid I)
Synonyms: 3,4-Methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acid • 313-67-7 • 8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid • 8-Methoxy-6-nitrophenanthol (3,4-d) 1,3-dioxole-5-carboxylic acid • 8-Methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid • Aristolochic acid • Aristolochic acid A • Aristolochic acid I • Aristolochic acid-I • Aristolochin • ARISTOLOCHINE • Birthwort • C17H11NO7 • CHEMBL93353 • NSC-50413 • NSC11926 • NSC50413 • Tardolyt • TR 1736 • UNII-94218WFP5T
CAS Number: 313-67-7
IUPAC Name: 8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
PubChem CID: 2236

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for NSC 11926 (Aristolochic acid I)

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for NSC 11926 (Aristolochic acid I)

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for NSC 11926 (Aristolochic acid I)

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id