DrugAge entry for N-tert-butyl-alpha-phenylnitrone

Name: N-tert-butyl-alpha-phenylnitrone
Synonyms: (Z)-benzylidene(tert-butyl)azane oxide • (Z)-N-Benzylidene-2-methylpropan-2-amine oxide • 2-Phenyl-N-tert-butylnitrone • 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide • 3376-24-7 • alpha-PBN • alpha-phenyl-N-tert-butyl nitrone • alpha-Phenyl-N-tert-butylnitrone • alpha-phenyl-t-butyl nitrone • alpha-Phenyl-t-butylnitrone • alpha-phenyl-tert-butylnitrone • C-Phenyl-N-tert-butylnitrone • MFCD00008799 • N-Benzylidene-tert-butylamine N-oxide • N-t-Butyl-alpha-phenylnitrone • N-tert-butyl-1-phenylmethanimine oxide • N-tert-Butyl-a-phenylnitrone • n-tert-butyl-alpha-phenylnitrone • N-tert-Butyl-C-phenylnitrone • N-tert-butylphenylnitrone • Phenyl N-t-butylnitrone • Phenyl-N-tert-butylnitrone • phenyl-tert-butylnitrone • ST51001119 • tert Butylphenylnitrone
CAS Number: 3376-24-7
IUPAC Name: N-tert-butyl-1-phenylmethanimine oxide
PubChem CID: 638877

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for N-tert-butyl-alpha-phenylnitrone

Average/Median Lifespan
Max Lifespan
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References

Saito, K et al. (1998) A spin trap, N-tert-butyl-alpha-phenylnitrone extends the life span of mice. Biosci. Biotechnol. Biochem. 62(4)792-794 PubMed

DGIdb Human Drug-Gene Interactions for N-tert-butyl-alpha-phenylnitrone

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for N-tert-butyl-alpha-phenylnitrone

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id