DrugAge entry for N-acetyl-L-cysteine

Name: N-acetyl-L-cysteine
Synonyms: 616-91-1 • Acetadote • Acetein • Acetilcisteina • acetylcysteine • Acetylcysteinum • Airbron • Broncholysin • Brunac • Fabrol • Fluimicil Infantil • Fluimucetin • Fluimucil • Flumucetin • Fluprowit • L-Acetylcysteine • Lysomucil • mercapturic acid • Mucomyst • Mucosil • Mucosolvin • N-Acetyl-cysteine • N-Acetyl-L-cysteine • N-Acetylcysteine • Parvolex
CAS Number: 616-91-1
IUPAC Name: (2R)-2-acetamido-3-sulfanylpropanoic acid
PubChem CID: 12035
SEP-L1000 side effects: Abdominal pain, Agitation, Angioedema, Asthenia, Confusional state, Constipation, Cough, Diarrhoea, Dizziness, Dry mouth, Dyspnoea, Headache, Hyperhidrosis, Hypersensitivity, Hypertension, Hypotension, Insomnia, Malaise, Nausea, Nervousness, Oedema, Pain, Paraesthesia, Pruritus, Rash, Somnolence, Tachycardia, Urticaria, Vertigo, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for N-acetyl-L-cysteine

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Brack, C et al. (1997) N-acetylcysteine slows down ageing and increases the life span of Drosophila melanogaster. Cell. Mol. Life Sci. 53(11-12)960-966 PubMed
Shibamura, A et al. (2009) A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan. Mech. Ageing Dev. 130(9)652-655 PubMed
Oh, SI et al. (2015) Lifespan extension and increased resistance to environmental stressors by N-acetyl-L-cysteine in Caenorhabditis elegans. Clinics (Sao Paulo) 70(5)380-386 PubMed
Desjardins D, et al. (2017) Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. Aging Cell () PubMed
Shaposhnikov MV, et al. (2018) Effects of N-acetyl-L-cysteine on lifespan, locomotor activity and stress-resistance of 3 Drosophila species with different lifespans Aging () PubMed
Ivan Gusarov (2021) Dietary thiols accelerate aging of C. elegans Nature Communications 12(1)4336 PubMed
Niraula, P et al. (2019) N-Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression Biogerontology () PubMed
Flurkey, K et al. (2010) Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 65(12)1275-1284 PubMed

DGIdb Human Drug-Gene Interactions for N-acetyl-L-cysteine

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for N-acetyl-L-cysteine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id