DrugAge entry for N-acetyl-L-cysteine

616-91-1 • Acetadote • Acetein • Acetilcisteina • acetylcysteine • Acetylcysteinum • Airbron • Broncholysin • Brunac • Fabrol • Fluimicil Infantil • Fluimucetin • Fluimucil • Flumucetin • Fluprowit • L-Acetylcysteine • Lysomucil • mercapturic acid • Mucomyst • Mucosil • Mucosolvin • N-Acetyl-cysteine • N-Acetyl-L-cysteine • N-Acetylcysteine • Parvolex 
CAS Number
(2R)-2-acetamido-3-sulfanylpropanoic acid 
PubChem CID
SEP-L1000 side effects
Abdominal pain, Agitation, Angioedema, Asthenia, Confusional state, Constipation, Cough, Diarrhoea, Dizziness, Dry mouth, Dyspnoea, Headache, Hyperhidrosis, Hypersensitivity, Hypertension, Hypotension, Insomnia, Malaise, Nausea, Nervousness, Oedema, Pain, Paraesthesia, Pruritus, Rash, Somnolence, Tachycardia, Urticaria, Vertigo, Vomiting 


Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)


Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for N-acetyl-L-cysteine


Brack, C et al. (1997) N-acetylcysteine slows down ageing and increases the life span of Drosophila melanogaster. Cell. Mol. Life Sci. 53(11-12)960-966 PubMed
Shibamura, A et al. (2009) A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan. Mech. Ageing Dev. 130(9)652-655 PubMed
Flurkey, K et al. (2010) Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 65(12)1275-1284 PubMed
Oh, SI et al. (2015) Lifespan extension and increased resistance to environmental stressors by N-acetyl-L-cysteine in Caenorhabditis elegans. Clinics (Sao Paulo) 70(5)380-386 PubMed
Desjardins D, et al. (2017) Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. Aging Cell () PubMed

DGIdb Human Drug-Gene Interactions for N-acetyl-L-cysteine

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for N-acetyl-L-cysteine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id