DrugAge entry for Myriocin

Name
Myriocin 
Synonyms
(+)-Myriocin • (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid • (2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid • (E,2S,3R,4R)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid • 35891-70-4 • 6-Eicosenoic acid, 2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-, (2S-(2R*,3S*,4S*,6E))- • antibiotic ISP-I • BIM1005 • C21H39NO6 • CAS-35891-70-4 • CHEBI:582124 • D07MQF • DSSTox_CID_26360 • DSSTox_GSID_46360 • DSSTox_RID_81561 • ISP-1 • ISP-I • Myriocin • Myriocin, Mycelia sterilia • NCGC00163597-02 • NCGC00163597-03 • thermozymocidin • UNII-YRM4E8R9ST • YRM4E8R9ST • [2S,3R,4R]-(E)-2-Amino-3,4-dihydroxy-2-[hydroxymethyl]-14-oxo-6-eicosenoic Acid 
CAS Number
35891-70-4 
IUPAC Name
(E,2S,3R,4R)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid 
PubChem CID
6438394 
SEP-L1000 side effects
Abdominal pain, Anxiety, Arthralgia, Body temperature increased, Bradycardia, Conjunctivitis, Constipation, Decreased appetite, Diarrhoea, Dizziness, Dyspepsia, Erythema, Headache, Hypersensitivity, Hypertension, Infection, Insomnia, Malaise, Nausea, Oedema, Pain, Paraesthesia, Pruritus, Rash, Syncope, Urticaria, Vomiting 

Summary

Species No. Entries MAX(Avg/Med Lifespan Change %) MEAN(Avg/Med Lifespan Change %) MAX(Max Lifespan Change %) MEAN(Max Lifespan Change %)

Results

Compound/Formulation Species Sex Strain Dosage Avg/Med Lifespan Change (%) Avg/Med Lifespan Significance Max Lifespan Change (%) Reference

Lifespan Charts for Myriocin


References

Liu, J et al. (2013) Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan. Aging Cell 12(5)833-841 PubMed
Roy G Cutler (2014) Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans Mechanisms of Ageing and Development 143-144()9-18 PubMed

DGIdb Human Drug-Gene Interactions for Myriocin

Interaction Types Gene Symbol Common Name HGNC Id DGIdb Sources References

Stitch DB Human Drug-Protein Interactions for Myriocin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id