DrugAge entry for Monorden

Name: Monorden
Synonyms: (1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione • 12772-57-5 • 1bgq • 2wer • 2zbk • 3cgy • 4egk • CHEBI:556075 • CHEMBL414883 • I60EH8GECX • MFCD06795865 • Microlactone, 1 • Monorden A • Monorderne • radicicol • Radicolol • Radisicol • RDC • RHI-12648 • UNII-I60EH8GECX
CAS Number: 12772-57-5
IUPAC Name: (4R,6R,8R,9Z,11E)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione
PubChem CID: 6323491

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Monorden

Average/Median Lifespan
Max Lifespan
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References

Janssens, GE et al. (2019) Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell Rep 27(2)467-480.e6 PubMed

DGIdb Human Drug-Gene Interactions for Monorden

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Monorden

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id