DrugAge entry for Minocycline

Name: Minocycline
Synonyms: 10118-90-8 • 7-Dimethylamino-6-demethyl-6-deoxytetracycline • Arestin • Borymycin • CHEBI:50694 • CL 59806 • Dynacin • HSDB 3130 • Klinomycin • MINO • Minociclina • Minociclina [INN-Spanish] • minociclinum • Minocin • Minocin (Hydrochloride) • Minocline • Minocyclin • minocycline • Minocycline Monohydrochloride • Minocycline [USAN:BAN:INN] • Minocyclinum • Minocyclinum [INN-Latin] • Minocyn • Minomycin • Tri-minocycline • UNII-FYY3R43WGO
CAS Number: 10118-90-8
IUPAC Name: (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
PubChem CID: 54675783
SEP-L1000 side effects: Abdominal pain, Acute hepatic failure, Agranulocytosis, Alopecia, Anaemia, Anaphylactic shock, Anaphylactoid reaction, Angioedema, Antinuclear antibody positive, Arthralgia, Arthritis, Aspartate aminotransferase increased, Asthma, Back pain, Balanitis, Benign intracranial hypertension, Bronchospasm, Cholestasis, Colitis, Constipation, Convulsion, Cough, Death, Decreased appetite, Dental caries, Dermatitis, Dermatitis exfoliative, Diarrhoea, Discomfort, Dizziness, Drug eruption, Dry mouth, Dyspepsia, Dysphagia, Dyspnoea, Enterocolitis, Eosinophilia, Erythema, Erythema multiforme, Erythema nodosum, Fatigue, Gingivitis, Glossitis, Haemolytic anaemia, Headache, Hearing impaired, Hepatic failure, Hepatitis, Hyperbilirubinaemia, Hypersensitivity, Hypertension, Hypoaesthesia, Injection site pain, Interstitial lung disease, Intracranial pressure increased, Jaundice, Joint stiffness, Joint swelling, Leukopenia, Local reaction, Lung infiltration, Lymphadenopathy, Malaise, Mass, Menorrhagia, Mouth ulceration, Mucous mem

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Minocycline

Average/Median Lifespan
Max Lifespan
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References

Bonilla, E et al. (2012) Minocycline increases the life span and motor activity and decreases lipid peroxidation in manganese treated Drosophila melanogaster. Toxicology 294(1)50-53 PubMed
Oxenkrug, G et al. (2012) Minocycline effect on life and health span of Drosophila melanogaster. Aging Dis 3(5)352-359 PubMed
Mora, M et al. (2013) Minocycline, but not ascorbic acid, increases motor activity and extends the life span of Drosophila melanogaster. Invest Clin 54(2)161-170 PubMed
Gang Jun Lee et al. (2017) Minocycline treatment increases resistance to oxidative stress and extends lifespan in Drosophila via FOXO Oncotarget () PubMed
Solis GM, et al. (2018) Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms eLife () PubMed
Strong, R et al. (2020) Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects. Aging cell 19(11)e13269 PubMed

DGIdb Human Drug-Gene Interactions for Minocycline

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Minocycline

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id