DrugAge entry for Milnacipran Hydrochloride

Name: Milnacipran Hydrochloride
Synonyms: (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide;hydrochloride • (1R-cis)-Milnacipran Hydrochloride • 1-Phenyl-1-(diethylaminocarbonyl)-2-(aminomethyl)cyclopropane hydrochloride • 101152-94-7 • 175131-61-0 • CHEMBL1237129 • cis-(+-)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride • DSSTox_CID_26785 • DSSTox_GSID_46785 • DSSTox_RID_81903 • F 2207 • F2207 • Midalcipran hydrochloride • Milnacipran (hydrochloride) • Milnacipran HCl • Milnacipran hydrochloride • Milnacipran hydrochloride [USAN] • MLS000758229 • MLS001424149 • NCGC00168780-01 • Savella • Savella (TN) • SCHEMBL161558 • SMR000449266 • Toledomin (TN)
CAS Number: 101152-94-7
IUPAC Name: (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide;hydrochloride
PubChem CID: 163701

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Milnacipran Hydrochloride

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Milnacipran Hydrochloride

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Milnacipran Hydrochloride

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id