DrugAge entry for Mifepristone

Name: Mifepristone
Synonyms: 320T6RNW1F • 84371-65-3 • CHEBI:50692 • Corlux • Korlym • Mifegyne • Mifeprex • Mifepriston • Mifepristone, 98% • MLS000069785 • NCGC00025179-05 • RU 38486 • RU 486 • RU-38486 • RU-486 • RU486 • SMR000058481 • UNII-320T6RNW1F • VGX-410 • VGX-410C
CAS Number: 84371-65-3
IUPAC Name: (8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
PubChem CID: 55245

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Mifepristone

Average/Median Lifespan
Max Lifespan
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References

Landis, GN et al. (2021) Metabolic Signatures of Life Span Regulated by Mating, Sex Peptide, and Mifepristone/RU486 in Female Drosophila melanogaster. J Gerontol A Biol Sci Med Sci 76(2)195-204 PubMed
John Tower (2017) Mifepristone/RU486 acts in Drosophila melanogaster females to counteract the life span-shortening and pro-inflammatory effects of male Sex Peptide Biogerontology 18(3)413-427 PubMed

DGIdb Human Drug-Gene Interactions for Mifepristone

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Mifepristone

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id