DrugAge entry for Metoprolol

Name
Metoprolol 
Synonyms
(RS)-Metoprolol • 37350-58-6 • 51384-51-1 • Beatrolol • Beloc-Duriles • Betaloc • Betalok • dl-Metoprolol • Lopresor • Lopresoretic • Lopressor • Meijoprolol • Metohexal • metoprolol • Metoprolol succinate • Metoprololum • Preblok • Presolol • Selo-Zok • Seloken • Seroken • Spesicor • Spesikor • Toprol • TOPROL-XL 
CAS Number
51384-51-1 
IUPAC Name
1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol 
PubChem CID
4171 
SEP-L1000 side effects
Abdominal pain, Abdominal pain upper, Abnormal dreams, Agranulocytosis, Alopecia, Amnesia, Anxiety, Arrhythmia, Arthralgia, Arthritis, Asthenia, Atrioventricular block, Atrioventricular block complete, Body temperature increased, Bradycardia, Bronchospasm, Cardiac arrest, Cardiac failure congestive, Cardiac output decreased, Cardiovascular disorder, Catatonia, Cerebrovascular accident, Chest pain, Coma, Confusional state, Conjunctivitis, Constipation, Cyanosis, Death, Depression, Diabetes mellitus, Diarrhoea, Disorientation, Dizziness, Dry eye, Dry mouth, Dysgeusia, Dyspepsia, Dyspnoea, Dyspnoea exertional, Erectile dysfunction, Eye pruritus, Fatigue, Fibrosis, Flatulence, Flushing, Gangrene, Gastric disorder, Gastrointestinal disorder, Hallucination, Headache, Hepatic function abnormal, Hepatitis, Hot flush, Hyperhidrosis, Hypoglycaemia, Hypotension, Insomnia, Intermittent claudication, Jaundice, Laryngospasm, Leukopenia, Libido decreased, Memory impairment, Mood swings, Muscle spasms, Musculoskeletal pain,  

Summary

Species No. Entries MAX(Avg/Med Lifespan Change %) MEAN(Avg/Med Lifespan Change %) MAX(Max Lifespan Change %) MEAN(Max Lifespan Change %)

Results

Compound/Formulation Species Sex Strain Dosage Avg/Med Lifespan Change (%) Avg/Med Lifespan Significance Max Lifespan Change (%) Reference

Lifespan Charts for Metoprolol


References

Spindler, SR et al. (2013) \u03b21-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice. Age (Dordr) 35(6)2099-2109 PubMed

DGIdb Human Drug-Gene Interactions for Metoprolol

Interaction Types Gene Symbol Common Name HGNC Id DGIdb Sources References

Stitch DB Human Drug-Protein Interactions for Metoprolol

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id