DrugAge entry for Metformin

Name
Metformin 
Synonyms
1,1-Dimethylbiguanide • 657-24-9 • Diabetosan • Diabex • Dimethylbiguanide • DMGG • Fluamine • Flumamine • Glifage • Gliguanid • Glucophage • Glumetza • Haurymelin • Islotin • Melbin • metformin • Metformina • Metformine • Metforminum • Metiguanide • N,N-Dimethylbiguanide • N,N-dimethylimidodicarbonimidic diamide • N1,N1-Dimethylbiguanide • NNDG • Siofor 
CAS Number
657-24-9 
IUPAC Name
3-(diaminomethylidene)-1,1-dimethylguanidine 
PubChem CID
4091 
SEP-L1000 side effects
Abdominal discomfort, Abdominal distension, Abdominal pain, Abdominal pain upper, Abnormal faeces, Abscess, Anaemia, Anaemia megaloblastic, Angina pectoris, Angina unstable, Angiopathy, Asthenia, Azotaemia, Blood disorder, Blood glucose decreased, Breast disorder, Cardiac disorder, Chest discomfort, Chest pain, Chills, Connective tissue disorder, Constipation, Decreased appetite, Dehydration, Dermatitis, Diarrhoea, Discomfort, Dizziness, Dysgeusia, Dyspepsia, Dyspnoea, Ear pain, Emotional distress, Epigastric discomfort, Erythema, Eye disorder, Fatigue, Flatulence, Flushing, Fungal infection, Gastric disorder, Gastroenteritis, Gastrointestinal disorder, Gastrointestinal tract irritation, Headache, Hepatitis, Hyperhidrosis, Hypertension, Hypoaesthesia, Hypoglycaemia, Immune system disorder, Infection, Infestation, Influenza, Lactic acidosis, Lethargy, Liver function test abnormal, Malaise, Mediastinal disorder, Migraine, Muscle spasms, Myalgia, Nail disorder, Nasal congestion, Nausea, Nervous system disorder,  

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Metformin


References

Smith, DL et al. (2010) Metformin supplementation and life span in Fischer-344 rats. J. Gerontol. A Biol. Sci. Med. Sci. 65(5)468-474 PubMed
Onken, B and Driscoll, M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS ONE 5(1)e8758 PubMed
Slack, C et al. (2012) Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila. PLoS ONE 7(10)e47699 PubMed
Martin-Montalvo, A et al. (2013) Metformin improves healthspan and lifespan in mice. Nat Commun 4()2192 PubMed
De Haes, W et al. (2014) Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. Proc. Natl. Acad. Sci. U.S.A. 111(24)E2501-E2509 PubMed
Hans, H et al. (2015) Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension? Age (Dordr) 37(2)31 PubMed
Dehghan E, (2017) Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway Nat Commun () PubMed
Chen J, et al. (2017) Metformin extends C. elegans lifespan through lysosomal pathway. ELife () PubMed
Alfaras I, et al. (2017) Health benefits of late-onset metformin treatment every other week in mice. NPJ Aging Mech Dis () PubMed
Wu L, et al. (2016) An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer. Cell () PubMed

DGIdb Human Drug-Gene Interactions for Metformin

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Metformin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id