DrugAge entry for Memantine Hydrochloride

Name: Memantine Hydrochloride
Synonyms: (3,5-Dimethyl-1-adamantyl)amine hydrochloride • 1-Amino-3,5-dimethyladamantane Hydrochloride • 3,5-Dimethyl-1-adamantanamine hydrochloride • 3,5-Dimethyl-1-aminoadamantane hydrochloride • 3,5-dimethyladamantan-1-amine hydrochloride • 3,5-dimethyladamantan-1-amine;hydrochloride • 3,5-dimethyladamantan-1-aminium chloride • 41100-52-1 • Akatinol • Axura • CHEBI:64323 • D-145 • Ebixa • JY0WD0UA60 • memantine • Memantine (hydrochloride) • Memantine HCL • MEMANTINE HYDROCHLORIDE • memantine.HCl • MFCD00214336 • MLS001332605 • Namenda • Namenda XR • SUN-Y7017 • UNII-JY0WD0UA60
CAS Number: 41100-52-1
IUPAC Name: 3,5-dimethyladamantan-1-amine;hydrochloride
PubChem CID: 181458

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Memantine Hydrochloride

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Memantine Hydrochloride

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Memantine Hydrochloride

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id