DrugAge entry for Loxapine

Name: Loxapine
Synonyms: 1977-10-2 • 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine • Adasuve • CL-62362 • Cloxazepine • Dibenzacepin • Dibenzoazepine • HF 3170 • HF3170 • Loxapac • Loxapin • Loxapina • Loxapinum • Loxitane • Loxitane IM • LW 3170 • Oxilapine • S-805 • SUM 3170 • SUM-3170
CAS Number: 1977-10-2
IUPAC Name: 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine
PubChem CID: 3964

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Loxapine

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Loxapine

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Loxapine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id