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DrugAge entry for Lithocholic acid

Name
Lithocholic acid 
Synonyms
(3-alpha,5-beta)-3-Hydroxycholan-24-oic acid • (3alpha,5beta)-3-hydroxycholan-24-oic acid • 3-alpha-Hydroxy-5-beta-cholanic acid • 3-alpha-Hydroxycholanic acid • 3-Hydroxycholan-24-oic acid • 3alpha-Hydroxy-5beta-cholan-24-oic acid • 3alpha-Hydroxy-5beta-cholanate • 3alpha-Hydroxy-5beta-cholanic acid • 3alpha-Hydroxy-5beta-cholanoic acid • 3alpha-Hydroxycholanic acid • 434-13-9 • 5-beta-Cholanic acid, 3-alpha-hydroxy- • 5beta-Cholan-24-oic acid, 3alpha-hydroxy- • 5beta-Cholanic acid-3alpha-ol • BRN 3217757 • CCRIS 363 • Cholan-24-oic acid, 3-hydroxy-, (3alpha,5beta)- • EINECS 207-099-1 • HSDB 4113 • Lithocholate • LITHOCHOLIC ACID • Lithocolic acid • NCI-C03861 • NSC 657956 • NSC683770 • UNII-5QU0I8393U 
CAS Number
434-13-9 
IUPAC Name
(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid 
PubChem CID
9903 
SEP-L1000 side effects
Abdominal pain, Anxiety, Arrhythmia, Asthenia, Body temperature increased, Constipation, Decreased appetite, Diarrhoea, Dizziness, Dyspepsia, Erythema, Headache, Hyperhidrosis, Hypersensitivity, Hypertension, Infection, Insomnia, Malaise, Nausea, Oedema, Pain, Paraesthesia, Pruritus, Rash, Thrombocytopenia, Urticaria, Visual impairment 

Summary

Species No. Entries MAX(Avg/Med Lifespan Change %) MEAN(Avg/Med Lifespan Change %) MAX(Max Lifespan Change %) MEAN(Max Lifespan Change %)

Results

Compound/Formulation Species Sex Strain Dosage Avg/Med Lifespan Change (%) Avg/Med Lifespan Significance Max Lifespan Change (%) Reference

Lifespan Charts for Lithocholic acid


References

Goldberg, AA et al. (2010) Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes. Aging (Albany NY) 2(7)393-414 PubMed
Arlia-Ciommo A,et al. (2018) Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions Oncotarget () PubMed
Staats S, et al. (2018) Lithocholic Acid Improves the Survival of Drosophila Melanogaster Molecular nutrition and food research () PubMed

DGIdb Human Drug-Gene Interactions for Lithocholic acid

Interaction Types Gene Symbol Common Name HGNC Id DGIdb Sources References

Stitch DB Human Drug-Protein Interactions for Lithocholic acid

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id