DrugAge entry for Lamotrigine

Name: Lamotrigine
Synonyms: 1,2,4-Triazine-3,5-diamine, 6-(2,3-dichlorophenyl)- • 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine • 3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine • 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine • 84057-84-1 • BW 430C • BW-430C • C9H7Cl2N5 • CHEBI:6367 • CHEMBL741 • EINECS 281-901-8 • Labileno • Lamictal • Lamictal (TN) • Lamictal Cd • Lamictal ODT • Lamictal XR • Lamictin • Lamiktal • Lamitor • Lamotrigina • Lamotrigina [Spanish] • lamotrigine • Lamotrigine [USAN:INN:BAN] • Lamotrigine, 98% • Lamotriginum • Lamotriginum [Latin] • LTG;BW430C • MFCD00865333 • MLS000069685 • U3H27498KS • UNII-U3H27498KS
CAS Number: 84057-84-1
IUPAC Name: 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
PubChem CID: 3878
SEP-L1000 side effects: Abdominal distension, Abdominal pain, Abscess, Accommodation disorder, Acne, Ageusia, Agitation, Agranulocytosis, Akathisia, Alanine aminotransferase increased, Alcohol intolerance, Alopecia, Amblyopia, Amenorrhoea, Amnesia, Anaemia, Angina pectoris, Angioedema, Anorgasmia, Anxiety, Apathy, Aphasia, Aplasia, Aplasia pure red cell, Aplastic anaemia, Apnoea, Arthralgia, Arthritis, Arthropathy, Aspartate aminotransferase increased, Asthenia, Asthma, Ataxia, Atrial fibrillation, Atrophy, Back pain, Blood disorder, Breast feeding, Breast neoplasm, Breast pain, Breath odour, Bronchitis, Bronchospasm, Bursitis, Candida infection, Cardiac fibrillation, Cerebellar syndrome, Cerebrovascular accident, Chest pain, Chills, Choreoathetosis, Colitis, Completed suicide, Confusional state, Conjunctivitis, Constipation, Convulsion, Coordination abnormal, Cough, Cystitis, Deafness, Death, Decreased appetite, Deep vein thrombosis, Deficiency anaemia, Delirium, Delusion, Depersonalisation, Depressed level of consciousness, Dermat

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Lamotrigine

Average/Median Lifespan
Max Lifespan
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References

Avanesian, A et al. (2010) Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster. Biogerontology 11(1)45-52 PubMed
Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Lamotrigine

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Lamotrigine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id