DrugAge entry for LY-294002

Name: LY-294002
Synonyms: 154447-36-6 • 15447-36-6 • 2-(4-morpholino)-8-phenyl-4H-1-benzopyran-4-one • 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one • 2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one • 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE • 2-morpholin-4-yl-8-phenyl-4H-chromen-4-one • 2-morpholin-4-yl-8-phenylchromen-4-one • 2-morpholino-8-phenyl-4H-chromen-4-one • 2-morpholino-8-phenyl-chromen-4-one • 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- • 8-Phenyl-2-(morpholin-4-yl)-chromen-4-one • AK162301 • BMK1-D5 • CHEBI:65329 • CHEMBL98350 • IN1266 • IN1268 • InSolution™ LY 294002 • LY 294002 • LY-294,002 • LY-294002 • LY2 • LY294002 • Lys 294002
CAS Number: 154447-36-6
IUPAC Name: 2-morpholin-4-yl-8-phenylchromen-4-one
PubChem CID: 3973
SEP-L1000 side effects: Abdominal pain, Anaemia, Asthenia, Body temperature increased, Constipation, Decreased appetite, Diarrhoea, Dizziness, Dyspnoea, Erythema, Headache, Hyperhidrosis, Hypertension, Hypotension, Insomnia, Malaise, Myalgia, Nausea, Oedema, Pain, Palpitations, Pruritus, Rash, Tachycardia, Thrombocytopenia, Urticaria, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for LY-294002

Average/Median Lifespan
Max Lifespan
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References

Moskalev, AA and Shaposhnikov, MV (2010) Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster. Rejuvenation Res 13(2-3)246-247 PubMed
Calvert, S et al. (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15(2)256-266 PubMed
Parveen Babar (1999) P13-kinase inhibition induces dauer formation, thermotolerance and longevity in C. elegans Neurobiology of Aging 20(5)513-519 PubMed

DGIdb Human Drug-Gene Interactions for LY-294002

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for LY-294002

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id