DrugAge entry for L2-Cmu (IGF-1R antagonist)

Name: L2-Cmu (IGF-1R antagonist)
Synonyms: IGF-1R mAb
CAS Number
IUPAC Name: IGF-1R antagonist
PubChem CID

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for L2-Cmu (IGF-1R antagonist)

Average/Median Lifespan
Max Lifespan
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References

Mao K, et al. (2018) Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice Nature communications () PubMed

DGIdb Human Drug-Gene Interactions for L2-Cmu (IGF-1R antagonist)

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for L2-Cmu (IGF-1R antagonist)

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id