DrugAge entry for L-deprenyl

(-)-Deprenil • (-)-selegiline • (R)-(-)-N,alpha-Dimethyl-N-2-propinylphenethylamine • 14611-51-9 • Anipryl • Carbex • CHEBI:9086 • CHEMBL972 • Eldepryl • Emsam • Jumex • L-Deprenalin • L-Deprenyl • l-E 250 • N-methyl-N-[(2R)-1-phenylpropan-2-yl]prop-2-yn-1-amine • Otrasel • Selegilina • Selegilina [INN-Spanish] • selegiline • Selegiline Hcl • Selegilinum • Selegilinum [INN-Latin] • STK640578 • UNII-2K1V7GP655 • Zelapar 
CAS Number
PubChem CID


Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)


Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for L-deprenyl


Milgram, NW et al. (1990) Maintenance on L-deprenyl prolongs life in aged male rats. Life Sci. 47(5)415-420 PubMed
Kitani, K et al. (1994) (-)Deprenyl increases the life span as well as activities of superoxide dismutase and catalase but not of glutathione peroxidase in selective brain regions in Fischer rats. Ann. N. Y. Acad. Sci. 717()60-71 PubMed
Archer, JR and Harrison, DE (1996) L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males. J. Gerontol. A Biol. Sci. Med. Sci. 51(6)B448-B453 PubMed
Kitani, K et al. (1993) Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats. Further evidence. Life Sci. 52(3)281-288 PubMed
Stoll, S et al. (1997) Chronic treatment of Syrian hamsters with low-dose selegiline increases life span in females but not males. Neurobiol. Aging 18(2)205-211 PubMed
Ruehl, WW et al. (1997) Treatment with L-deprenyl prolongs life in elderly dogs. Life Sci. 61(11)1037-1044 PubMed
Kitani, K et al. (2005) Dose-dependency of life span prolongation of F344/DuCrj rats injected with (-)deprenyl. Biogerontology 6(5)297-302 PubMed

DGIdb Human Drug-Gene Interactions for L-deprenyl

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for L-deprenyl

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id