DrugAge entry for L-Carnitine

Name: L-Carnitine
Synonyms: (-)-Carnitine • (-)-L-Carnitine • (3R)-3-hydroxy-4-(trimethylammonio)butanoate • (R)-Carnitine • 541-15-1 • bicarnesine • Carniking • Carniking 50 • Carnilean • Carnitene • Carnitine • Carnitine, (-)- • Carnitolo • Carnitor • Carnovis • Carrier • gamma-Trimethyl-beta-hydroxybutyrobetaine • Karnitin • L(-)-Carnitine • L-(-)-Carnitine • L-carnitine • L-Carnitine inner salt • Lefcar • Levocarnitina • Levocarnitina [Spanish] • Levocarnitine • Levocarnitinum • Levocarnitinum [Latin] • Metina • vitamin BT
CAS Number: 541-15-1
IUPAC Name: (3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate
PubChem CID: 10917

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for L-Carnitine

Average/Median Lifespan
Max Lifespan
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References

Palermo, V et al. (2010) Acetyl-L-carnitine protects yeast cells from apoptosis and aging and inhibits mitochondrial fission. Aging Cell 9(4)570-579 PubMed
Liu, D et al. (2020) Carnitine promotes recovery from oxidative stress and extends lifespan in Aging (Albany NY) 13(1)813-830 PubMed

DGIdb Human Drug-Gene Interactions for L-Carnitine

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for L-Carnitine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id