DrugAge entry for ISRIB

Name: ISRIB
Synonyms: 1597403-47-8 • 1597403-48-9 • 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide • 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide • 548470-11-7 • Acetamide, N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)- • AOB4545 • C7B • CHEMBL4303573 • cis-ISRIB;ISRIB • EX-A298 • HMS3887M19 • ISRIB • ISRIB (cis-isomer) • ISRIB (trans-isomer) • ISRIB trans-isomer • ISRIB(trans-isomer) • N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) • N,N'-(cis-Cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) • N,N'-(Cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) • N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide] • Oprea1_706389 • SCHEMBL16082980 • SCHEMBL16082988 • SCHEMBL16083047 • SYN5238 • trans-ISRIB
CAS Number
IUPAC Name: 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide
PubChem CID: 1011240

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for ISRIB

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Derisbourg, MJ et al. (2021) Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation. Nat Commun 12(1)1678 PubMed

DGIdb Human Drug-Gene Interactions for ISRIB

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for ISRIB

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id