DrugAge entry for IMS2186

Name: IMS2186
Synonyms: (3E)-2,3-Dihydro-3-[(3-hydroxy-4-methoxyphenyl)methylene]-6-methyl-4H-1-benzopyran-4-one • (3E)-3-[(3-hydroxy-4-methoxyphenyl)methylidene]-6-methylchromen-4-one • (E)-3-(3-hydroxy-4-methoxybenzylidene)-6-methylchroman-4-one • 1031206-36-6 • 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one • CCG-222394 • HMS3263I22 • IMS 2186 • IMS2186 • IMS2186, >=98% (HPLC), solid • J-000877 • LP01090 • NCGC00261775-01 • NCGC00386646-03 • SCHEMBL4732781 • SDCCGSBI-0633787.P001 • Tox21_501090 • ZINC44018876
CAS Number
IUPAC Name: (3E)-3-[(3-hydroxy-4-methoxyphenyl)methylidene]-6-methylchromen-4-one
PubChem CID: 24987039

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for IMS2186

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for IMS2186

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for IMS2186

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id