DrugAge entry for Hydralazine
Summary
| Species | No. Entries | MAX(Avg/Med Lifespan Change %) | MEAN(Avg/Med Lifespan Change %) | MAX(Max Lifespan Change %) | MEAN(Max Lifespan Change %) |
|---|
Results
| Compound/Formulation | Species | Sex | Strain | Dosage | Avg/Med Lifespan Change (%) | Avg/Med Lifespan Significance | Max Lifespan Change (%) | Reference |
|---|
Lifespan Charts for Hydralazine
- Average/Median Lifespan
- Max Lifespan
- Hide Charts
References
Dehghan E, (2017) Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway Nat Commun () PubMedSnell TW, et al. (2016) Repurposing FDA-approved drugs for anti-aging therapies. Biogerontology () PubMed
Dehghan, E et al. (2019) Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans. Nat Commun 10(1)4905 PubMed
Miller, RA et al. (2024) Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin. GeroScience 46(5)4657-4670 PubMed
DGIdb Human Drug-Gene Interactions for Hydralazine
| Interaction Types | Gene Symbol | Common Name | HGNC Id | DGIdb Sources | References |
|---|---|---|---|---|---|
Stitch DB Human Drug-Protein Interactions for Hydralazine
Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.
| Ensembl Id | StringDB Id |
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