DrugAge entry for Glycerol

Name
Glycerol 
Synonyms
1,2,3-Propanetriol • 1,2,3-trihydroxypropane • 56-81-5 • Dagralax • glycerin • Glycerin, anhydrous • Glycerin, synthetic • Glycerine • Glycerinum • Glyceritol • glycerol • Glycyl alcohol • Glyrol • Glysanin • Grocolene • Ophthalgan • Optim • Osmoglyn • Polyglycerine • PROPANE-1,2,3-TRIOL • Propanetriol • Synthetic glycerin • Synthetic glycerine • Trihydroxypropane • Vitrosupos 
CAS Number
56-81-5 
IUPAC Name
propane-1,2,3-triol 
PubChem CID
753 
SEP-L1000 side effects
Abdominal pain, Asthenia, Body temperature increased, Chest pain, Confusional state, Diarrhoea, Dizziness, Dyspnoea, Haemorrhage, Headache, Hyperhidrosis, Hypersensitivity, Insomnia, Nausea, Oedema, Pain, Paraesthesia, Pruritus, Rash, Somnolence, Tachycardia, Vomiting 

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Glycerol


References

Lee, SJ et al. (2009) Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 10(5)379-391 PubMed
Snell, TW and Johnston, RK (2014) Glycerol extends lifespan of Brachionus manjavacas (Rotifera) and protects against stressors. Exp. Gerontol. 57()47-56 PubMed
Edwards, C et al. (2015) Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans. BMC Genet. 16()8 PubMed
Anderson N, et al. (2016) C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins Mech Ageing Dev () PubMed

DGIdb Human Drug-Gene Interactions for Glycerol

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Glycerol

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id