DrugAge entry for Glycerol
- Name
- Glycerol
- Synonyms
- 1,2,3-Propanetriol • 1,2,3-trihydroxypropane • 56-81-5 • Dagralax • glycerin • Glycerin, anhydrous • Glycerin, synthetic • Glycerine • Glycerinum • Glyceritol • glycerol • Glycyl alcohol • Glyrol • Glysanin • Grocolene • Ophthalgan • Optim • Osmoglyn • Polyglycerine • PROPANE-1,2,3-TRIOL • Propanetriol • Synthetic glycerin • Synthetic glycerine • Trihydroxypropane • Vitrosupos
- CAS Number
- 56-81-5
- IUPAC Name
- propane-1,2,3-triol
- PubChem CID
- 753
- SEP-L1000 side effects
- Abdominal pain, Asthenia, Body temperature increased, Chest pain, Confusional state, Diarrhoea, Dizziness, Dyspnoea, Haemorrhage, Headache, Hyperhidrosis, Hypersensitivity, Insomnia, Nausea, Oedema, Pain, Paraesthesia, Pruritus, Rash, Somnolence, Tachycardia, Vomiting
Summary
| Species | No. Entries | MAX(Avg/Med Lifespan Change %) | MEAN(Avg/Med Lifespan Change %) | MAX(Max Lifespan Change %) | MEAN(Max Lifespan Change %) |
|---|
Results
| Compound/Formulation | Species | Sex | Strain | Dosage | Avg/Med Lifespan Change (%) | Avg/Med Lifespan Significance | Max Lifespan Change (%) | Reference |
|---|
Lifespan Charts for Glycerol
- Average/Median Lifespan
- Max Lifespan
- Hide Charts
References
Kaeberlein, M et al. (2002) High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol. Cell. Biol. 22(22)8056-8066 PubMedLee, SJ et al. (2009) Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 10(5)379-391 PubMed
Snell, TW and Johnston, RK (2014) Glycerol extends lifespan of Brachionus manjavacas (Rotifera) and protects against stressors. Exp. Gerontol. 57()47-56 PubMed
Edwards, C et al. (2015) Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans. BMC Genet. 16()8 PubMed
Anderson N, et al. (2016) C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins Mech Ageing Dev () PubMed
DGIdb Human Drug-Gene Interactions for Glycerol
| Interaction Types | Gene Symbol | Common Name | HGNC Id | DGIdb Sources | References |
|---|---|---|---|---|---|
Stitch DB Human Drug-Protein Interactions for Glycerol
Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.
| Ensembl Id | StringDB Id |
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