DrugAge entry for Glucose
- Name
- Glucose
- Synonyms
- (+)-Glucose • (3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol • 2280-44-6 • CHEBI:4167 • Clearsweet 95 • Clintose L • CPC hydrate • D-Glc • D-Glcp • D-Glucopyranose • D-Glucopyranoside • D-Glucose • DSSTox_CID_2910 • Glc • Glucan • Glucodin • Glucopyranose • Glucopyranose, D- • Glucopyranoside • Glucose • Glucose solution • Grape sugar • Meritose • Roferose ST • Staleydex 95M
- CAS Number
- 2280-44-6
- IUPAC Name
- (3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
- PubChem CID
- 5793
Summary
| Species | No. Entries | MAX(Avg/Med Lifespan Change %) | MEAN(Avg/Med Lifespan Change %) | MAX(Max Lifespan Change %) | MEAN(Max Lifespan Change %) |
|---|
Results
| Compound/Formulation | Species | Sex | Strain | Dosage | Avg/Med Lifespan Change (%) | Avg/Med Lifespan Significance | Max Lifespan Change (%) | Reference |
|---|
Lifespan Charts for Glucose
- Average/Median Lifespan
- Max Lifespan
- Hide Charts
References
Kaeberlein, M et al. (2002) High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol. Cell. Biol. 22(22)8056-8066 PubMedLee, SJ et al. (2009) Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 10(5)379-391 PubMed
Schulz TJ, et al. (2007) Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress () PubMed
Zheng J, et al. (2017) Lower Doses of Fructose Extend Lifespan in Caenorhabditis elegans J Diet Suppl () PubMed
Mendler M, et al. (2017) Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan Journal of Diabetes and its Complications () PubMed
Tauffenberger A, et al. (2016) Fragile lifespan expansion by dietary mitohormesis in C. elegans Aging () PubMed
DGIdb Human Drug-Gene Interactions for Glucose
| Interaction Types | Gene Symbol | Common Name | HGNC Id | DGIdb Sources | References |
|---|---|---|---|---|---|
Stitch DB Human Drug-Protein Interactions for Glucose
Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.
| Ensembl Id | StringDB Id |
|---|