DrugAge entry for Genistein
- Name
- Genistein
- Synonyms
- 4',5, 7-Trihydroxyisoflavone • 4',5,7-Trihydroxyisoflavone • 4,5,7-Trihydroxyiso-flavone • 446-72-0 • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)- • 5,7,4'-Trihydroxyisoflavone • 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone • 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one • 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one • 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one • Bio 300 • Bonistein • C.I. 75610 • CCRIS 7675 • CHEMBL44 • Differenol A • Genestein • genistein • Genisteol • Genisterin • ISOFLAVONE, 4',5,7-TRIHYDROXY- • Lactoferrin-genistein • MFCD00016952 • NPI 031L • NSC 36586 • NSC36586 • Prunetol • SIPI 807-1 • Sophoricol • UNII-DH2M523P0H
- CAS Number
- 446-72-0
- IUPAC Name
- 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
- PubChem CID
- 5280961
- SEP-L1000 side effects
- Abdominal pain, Anaemia, Asthenia, Constipation, Diarrhoea, Dizziness, Headache, Hyperhidrosis, Hypersensitivity, Insomnia, Nausea, Oedema, Pain, Paraesthesia, Pruritus, Rash, Syncope, Tachycardia, Urticaria, Vomiting
Summary
| Species | No. Entries | MAX(Avg/Med Lifespan Change %) | MEAN(Avg/Med Lifespan Change %) | MAX(Max Lifespan Change %) | MEAN(Max Lifespan Change %) |
|---|
Results
| Compound/Formulation | Species | Sex | Strain | Dosage | Avg/Med Lifespan Change (%) | Avg/Med Lifespan Significance | Max Lifespan Change (%) | Reference |
|---|
Lifespan Charts for Genistein
- Average/Median Lifespan
- Max Lifespan
- Hide Charts
References
Lee, EB et al. (2015) Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans. Biomol Ther (Seoul) 23(1)77-83 PubMedLombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed
Deniz Altun (2011) Determination of the effects of genistein on the longevity of Drosophila melanogaster meigen (Diptera; Drosophilidae) Bulletin of Environmental Contamination and Toxicology 86()120-123 PubMed
Rodrigo Dutra Nunes (2016) Polyphenol-Rich Diets Exacerbate AMPK-Mediated Autophagy, Decreasing Proliferation of Mosquito Midgut Microbiota, and Extending Vector Lifespan Plos Neglected Tropical Diseases 10(10)e0005034 PubMed
DGIdb Human Drug-Gene Interactions for Genistein
| Interaction Types | Gene Symbol | Common Name | HGNC Id | DGIdb Sources | References |
|---|---|---|---|---|---|
Stitch DB Human Drug-Protein Interactions for Genistein
Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.
| Ensembl Id | StringDB Id |
|---|