DrugAge entry for Geldanamycin

Name: Geldanamycin
Synonyms: (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate • 1yet • 2-Azabicyclo[16.3.1]docosane, geldanamycin deriv. • 30562-34-6 • AC1NRBEH • BRN 1633093 • BSPBio_001073 • CHEBI:5292 • DTXSID7042691 • GDM • geldanamycin • Geldanamycin (9CI) • Geldanamycin Ready Made Solution • Geldanamycin, Streptomyces hygroscopicus • Geldanamycin/ • geldanomycin • GTPL9829 • MFCD00274570 • NSC 122750 • NSC-122750 • SCHEMBL13037476 • SCHEMBL4154 • U 29135 • U-29135 • UNII-Z3K3VJ16KU • Z3K3VJ16KU • [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate • [8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione
CAS Number: 30562-34-6
IUPAC Name: [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
PubChem CID: 5288382
SEP-L1000 side effects: Abdominal pain, Alopecia, Anaemia, Asthenia, Back pain, Body temperature increased, Confusional state, Constipation, Decreased appetite, Diarrhoea, Dizziness, Dyspnoea, Erythema, Fatigue, Haemorrhage, Headache, Hyperhidrosis, Hypersensitivity, Hypertension, Hypotension, Infection, Insomnia, Leukopenia, Malaise, Nausea, Necrosis, Neuropathy peripheral, Neutropenia, Oedema, Pain, Pneumonia, Pruritus, Rash, Tachycardia, Thrombocytopenia, Ulcer, Urticaria, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Geldanamycin

Average/Median Lifespan
Max Lifespan
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References

Calvert, S et al. (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15(2)256-266 PubMed
Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Geldanamycin

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Geldanamycin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id