DrugAge entry for Gamma-tocopherol

Name: Gamma-tocopherol
Synonyms: (+)-.gamma.-Tocopherol • (+)-g-Tocopherol • (+)-gamma-Tocopherol • (2R)-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-ol • (2r)-2,7,8-trimethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]chroman-6-ol • (2R)-3,4-dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol • (R,R,R)-gamma-Tocopherol • 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, (2R)- • 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)- • 54-28-4 • 7,8-Dimethyltocol • AC1L3OPP • AC1Q7AUU • all-(R)-|A-Tocopherol • CHEBI:18185 • D-gamma-Tocopherol • DSSTox_CID_28957 • DSSTox_RID_83222 • EINECS 200-201-5 • gamma-Tocopherol • gamma-Tocopherol, d- • NCGC00185764-01 • QUEDXNHFTDJVIY-DQCZWYHMSA-N • RRR-gamma-Tocopherol • UNII-8EF1Z1238F
CAS Number: 54-28-4
IUPAC Name: (2R)-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
PubChem CID: 92729

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Gamma-tocopherol

Average/Median Lifespan
Max Lifespan
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References

Zou, S et al. (2007) Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech. Ageing Dev. 128(2)222-226 PubMed
Kashima, N et al. (2012) Development of a method for oral administration of hydrophobic substances to Caenorhabditis elegans: pro-longevity effects of oral supplementation with lipid-soluble antioxidants. Biogerontology 13(3)337-344 PubMed

DGIdb Human Drug-Gene Interactions for Gamma-tocopherol

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Gamma-tocopherol

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id