DrugAge entry for Flunarizine hydrochloride

Name: Flunarizine hydrochloride
Synonyms: (E)-1-(Bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazine dihydrochloride • 1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride • 1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride • 1-[BIS(4-FLUOROPHENYL)METHYL]-4-CINNAMYLPIPERAZINE DIHYDROCHLORIDE • 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine;dihydrochloride • 27064-95-5 • 30484-77-6 • C11102TO53 • C26H28Cl2F2N2 • EINECS 250-216-6 • Flugeral • Flunarizine (dihydrochloride) • Flunarizine 2HCl • Flunarizine diHCl • Flunarizine dihydrochloride • Flunarizine HCl • flunarizine hydrochloride • Flunarizine hydrochloride [USAN:JAN] • KW-3149 • MFCD00058198 • R 14,950 • R 14950 • Sibelium • SR-01000000006 • UNII-C11102TO53
CAS Number
IUPAC Name: 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine;dihydrochloride
PubChem CID: 5282407

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Flunarizine hydrochloride

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Flunarizine hydrochloride

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Flunarizine hydrochloride

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id