DrugAge entry for Flunarizine

Name: Flunarizine
Synonyms: (E)-1-(Bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazine • (E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine • 1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine • 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine • 40218-96-0 • 52468-60-7 • CHEMBL30008 • DSSTox_CID_25616 • DSSTox_GSID_45616 • DSSTox_RID_81005 • Flunarizina • Flunarizina [INN-Spanish] • Flunarizine [INN:BAN] • Flunarizinum • Flunarizinum [INN-Latin] • Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)-, (E)- • Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, (E)- • R7PLA2DM0J • Sibelium • UNII-R7PLA2DM0J
CAS Number: 52468-60-7
IUPAC Name: 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
PubChem CID: 941361

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Flunarizine

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Flunarizine

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Flunarizine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id