DrugAge entry for Fisetin
- Name
- Fisetin
- Synonyms
- 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one • 3,3',4',7-Tetrahydroxyflavone • 3,7,3',4'-Tetrahydroxyflavone • 5-Deoxyquercetin • 5-Desoxyquercetin • 528-48-3 • Bois bleu de Honqrie • BOIS bleude honqrie • C.I. 75620 • C.I. Natural Brown 1 • Cotinin • Fietin • Fisetholz • Fisetin • Fustel • Fustet • Junger fustik • Superfustel • Superfustel K • Ungarisches gelbholz • Ventin sumach • Viset • Young fustic • Young fustic crystals • Zante fustic
- CAS Number
- 528-48-3
- IUPAC Name
- 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one
- PubChem CID
- 5281614
Summary
| Species | No. Entries | MAX(Avg/Med Lifespan Change %) | MEAN(Avg/Med Lifespan Change %) | MAX(Max Lifespan Change %) | MEAN(Max Lifespan Change %) |
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Results
| Compound/Formulation | Species | Sex | Strain | Dosage | Avg/Med Lifespan Change (%) | Avg/Med Lifespan Significance | Max Lifespan Change (%) | Reference |
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Lifespan Charts for Fisetin
- Average/Median Lifespan
- Max Lifespan
- Hide Charts
References
Howitz, KT et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425(6954)191-196 PubMedWood, JG et al. (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430(7000)686-689 PubMed
Harrison, DE et al. (2024) Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used. GeroScience 46(1)795-816 PubMed
Yousefzadeh, MJ et al. (2018) Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine 36()18-28 PubMed
DGIdb Human Drug-Gene Interactions for Fisetin
| Interaction Types | Gene Symbol | Common Name | HGNC Id | DGIdb Sources | References |
|---|---|---|---|---|---|
Stitch DB Human Drug-Protein Interactions for Fisetin
Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.
| Ensembl Id | StringDB Id |
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