DrugAge entry for Ethosuximide

Name: Ethosuximide
Synonyms: 2-Ethyl-2-methylsuccinimide • 77-67-8 • Atysmal • Capitus • Emeside • Ethosuccimide • Ethosuccinimide • Ethosuxide • ethosuximide • Ethymal • Etosuximid • Etosuximida • Mesentol • Pemalin • Pentinimid • Peptinimid • Petinimid • Petnidan • Pyknolepsinum • Simatin • Succimitin • Suxilep • Suxinutin • Zaraondan • Zarontin
CAS Number: 77-67-8
IUPAC Name: 3-ethyl-3-methylpyrrolidine-2,5-dione
PubChem CID: 3291
SEP-L1000 side effects: Abdominal discomfort, Abdominal pain, Aggression, Agranulocytosis, Ataxia, Decreased appetite, Diarrhoea, Dizziness, Drug eruption, Emotional distress, Eosinophilia, Euphoric mood, Fatigue, Gastrointestinal disorder, Haematuria, Haemorrhage, Headache, Hiccups, Hirsutism, Hyperkinesia, Hypersensitivity, Hypertrophy, Irritability, Lethargy, Leukopenia, Libido increased, Muscle spasms, Myopia, Nausea, Pain, Paranoia, Psychotic disorder, Rash, Somnolence, Swelling, Swollen tongue, Systemic lupus erythematosus, Urticaria, Vaginal haemorrhage, Vomiting, Weight decreased

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Ethosuximide

Average/Median Lifespan
Max Lifespan
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References

Evason, K et al. (2005) Anticonvulsant medications extend worm life-span. Science 307(5707)258-262 PubMed
James J Collins (2008) The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan Plos Genetics 4(10)e1000230 PubMed

DGIdb Human Drug-Gene Interactions for Ethosuximide

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Ethosuximide

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id